Incorporating Hardy-Weinberg Equilibrium Law to Enhance the Association Strength for Ordinal Trait Genetic Study
نویسندگان
چکیده
منابع مشابه
the essentiality of reporting hardy-weinberg equilibrium calculations in population-based genetic association studies
population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. an essential quality control step in such studies is to undertake hardy-weinberg equilibrium (hwe) calculations. deviations from hwe in the control group may reflect important problems including selection bias, po...
متن کاملBayesian methods for examining Hardy-Weinberg equilibrium.
Testing for Hardy-Weinberg equilibrium is ubiquitous and has traditionally been carried out via frequentist approaches. However, the discreteness of the sample space means that uniformity of p-values under the null cannot be assumed, with enumeration of all possible counts, conditional on the minor allele count, offering a computationally expensive way of p-value calibration. In addition, the i...
متن کاملA clarification of the Hardy-Weinberg law.
C. C. Li showed that Hardy-Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting fro...
متن کاملThe Essentiality of Reporting Hardy-Weinberg Equilibrium Calculations in Population-Based Genetic Association Studies
Population-based genetic association studies have proven to be a powerful tool in identifying genes implicated in many complex human diseases that have a huge impact on public health. An essential quality control step in such studies is to undertake Hardy-Weinberg equilibrium (HWE) calculations. Deviations from HWE in the control group may reflect important problems including selection bias, po...
متن کاملRe-imagining the Hardy-Weinberg Law
Under random mating, a progeny's alleles are independently sampled from the parental gene pools. Here is a new proof which avoids the usual algebraic complexity, based on a restated Mendel's First Law. Another simplified proof along the old approach led to the discovery that allelic independence can hold under random mating and fertility selection. The theoretical existence and number of such s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 2015
ISSN: 0003-4800
DOI: 10.1111/ahg.12142